Relationship Between Homocysteine, Coronary Risk Factors, C-Reactive Protein, Bone Mineral Density and Carotid Circulation Among frail elderly
DEENA MOSTAFA MOHAMED HELMY ELMALEH;
Abstract
Frailty is a rather new concept in geriatric research and practice. Over the last decades, there has been an exponential rise in the use of the term “frailty” in the literature. Frail older people are at high risk for developing adverse outcomes as disability, morbidity, mortality, hospitalization and institutionalization. Frailty confers loss of independence and impairs the quality of life and psychological well-being of older
people. It also poses challenges on families, caregivers, and other structures of social care and support.
Given the prominent role of CVD in the aggregate burden of morbidity and mortality in the elderly, it was not surprising that CVD, was strongly correlated with frailty.
The Women’s Health Initiative Observational Study showed that community-dwelling older women with CVD and cardiovascular risk factors were at higher risk of developing incident frailty. Coronary artery disease and stroke were associated with the highest risk of developing incident frailty.
Osteoporosis often accompanies advanced frailty and any fragility fracture in this population is likely to have a profound impact on quality of life and may lead to permanent disability and even premature death. The multidimensional aspects of osteoporosis require a multidisciplinary integrated approach, including environmental, lifestyle, dietary and pharmacological interventions .
This study was conducted to compare frail & healthy elderly regarding Bone mineral density, carotid circulation and serum levels of Homocysteine, coronary risk factors and CRP.
This study is a case-control study performed on 104 elderly 60 years and older, male and female. They were divided into two groups:
Group A (case group): 52 frail elderly diagnosed by Fried’s criteria as applied by Avila-Funes et al., 2008.
Group B (control group): 52 healthy elderly .
Both groups were recruited from out patient clinics & in-patient wards at Ain Shams University hospital.
The 104 elderly were subjected to comprehensive geriatric assessment including personal history, past medical history, cognitive assessment using mini mental state examination (MMSE), depression assessment using geriatric depression
people. It also poses challenges on families, caregivers, and other structures of social care and support.
Given the prominent role of CVD in the aggregate burden of morbidity and mortality in the elderly, it was not surprising that CVD, was strongly correlated with frailty.
The Women’s Health Initiative Observational Study showed that community-dwelling older women with CVD and cardiovascular risk factors were at higher risk of developing incident frailty. Coronary artery disease and stroke were associated with the highest risk of developing incident frailty.
Osteoporosis often accompanies advanced frailty and any fragility fracture in this population is likely to have a profound impact on quality of life and may lead to permanent disability and even premature death. The multidimensional aspects of osteoporosis require a multidisciplinary integrated approach, including environmental, lifestyle, dietary and pharmacological interventions .
This study was conducted to compare frail & healthy elderly regarding Bone mineral density, carotid circulation and serum levels of Homocysteine, coronary risk factors and CRP.
This study is a case-control study performed on 104 elderly 60 years and older, male and female. They were divided into two groups:
Group A (case group): 52 frail elderly diagnosed by Fried’s criteria as applied by Avila-Funes et al., 2008.
Group B (control group): 52 healthy elderly .
Both groups were recruited from out patient clinics & in-patient wards at Ain Shams University hospital.
The 104 elderly were subjected to comprehensive geriatric assessment including personal history, past medical history, cognitive assessment using mini mental state examination (MMSE), depression assessment using geriatric depression
Other data
| Title | Relationship Between Homocysteine, Coronary Risk Factors, C-Reactive Protein, Bone Mineral Density and Carotid Circulation Among frail elderly | Other Titles | دراسة العلاقة بين الهوموسيستايين وعوامل الخطورة لضيق الشرايين التاجية و بروتين سي التفاعلي و كثافة العظام و الدورة الدموية بالشريان السباتي في المسنين المصابين بالوهن | Authors | DEENA MOSTAFA MOHAMED HELMY ELMALEH | Issue Date | 2014 |
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