Analytical study for the determination of some drugs used in treatment of masculinity diseases

Abstract

The present thesis includes the analytical studies for the determination of Verdenafil Hydrochloride (erectile dysfunction) and Dapoxetine Hydrochloride (premature ejaculation) in their pure powder or pharmaceutical preparations.

It comprises three chapters:

Chapter I: contains introduction on Verdenafil (VAR), Dapoxetine (DAP) and on the proposed methods for their determination, and also includes literature survey on the methods reported for their determination and on the selected methods for their analysis.

Chapter II: contains the experimental part which includes the materials, preparation of various solutions, apparatus used and general procedures for the developed methods for the determination of VAR and DAP.

Chapter III: contains the results and discussion, which contains the proposed methods for the determination of VAR and DAP in a mixture, which includes four parts:

Part 1: Simple and rapid spectrophotometric methods were developed for the simultaneous determination of VAR and DAP in mixtures which are:

i) Simultaneous equations method: The determinations were carried out at 291.7 and 245.5 nm for VAR and DAP, respectively. This method was applied on their pure and pharmaceutical preparation forms and gives good results.