PHYTOCHEMICAL AND BIOLOGICAL STUDY ON CERTAIN PLANTS BELONGING TO FAMILY SCROPHULARIACEAE
Fadia Salah Youssef;
Abstract
Family Scrophulariaceae is a large family with almost 87 genera and 4800 species. Eremophila (Scrophulariaceae) is an endemic Australian genus with 214 species, which is commonly known as Fuchsia bush, Emu bush or Poverty bush. Plants of this genus played an important role for the Australian Aborigines who used them widely for medicinal and ceremonial purposes.
The genus Eremophila possesses many biological and pharmacological activities such as antimicrobial, antiviral, antiproliferative, anti-inflammatory and immunomodulatory activities.
Although, many studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and their isolated secondary metabolites, there are still a lot to be explored. To the best of our knowledge, little biological and phytochemical studies were found in the available literature for Eremophila maculata (Ker Gawl.) F. Muell.
This study was divided into four main chapters:
Chapter (1): An in-depth comparative macro- and micromorphological study of the stems and leaves of two Eremophila species, viz E. maculata and E. purpurascens was done. Moreover, a comparative genetic study was done, in which the DNA of both plants was extracted from leaf samples and analyzed using 10 decamer random primers which will help in further standardization and quality control studies.
Chapter (2): A preliminary biological screening of Eremophila maculata methanol extract was carried out including the cytotoxicity, antimicrobial, antiviral, anti-allergic, in vitro antioxidant and hepatoprotective activity. The latter was further supported by an in vivo study together with an in vivo study of its antidiabetic activity.
Chapter (3): A preliminary phytochemical screening of Eremophila maculata leaves followed by an in-depth phytochemical study of its methanol extract was done. Further chromatographic separation was carried out to characterize and isolate the relevant compounds that may be responsible for the biological activity. Moreover, LC-MS run was done on the methanol extract with the aim to tentatively identify its chief active constituents.
Chapter (4): A comprehensive study was performed on the essential oils of Eremophila maculata leaf, flower, fresh and air-dried stems with the target to explore their chemical
The genus Eremophila possesses many biological and pharmacological activities such as antimicrobial, antiviral, antiproliferative, anti-inflammatory and immunomodulatory activities.
Although, many studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and their isolated secondary metabolites, there are still a lot to be explored. To the best of our knowledge, little biological and phytochemical studies were found in the available literature for Eremophila maculata (Ker Gawl.) F. Muell.
This study was divided into four main chapters:
Chapter (1): An in-depth comparative macro- and micromorphological study of the stems and leaves of two Eremophila species, viz E. maculata and E. purpurascens was done. Moreover, a comparative genetic study was done, in which the DNA of both plants was extracted from leaf samples and analyzed using 10 decamer random primers which will help in further standardization and quality control studies.
Chapter (2): A preliminary biological screening of Eremophila maculata methanol extract was carried out including the cytotoxicity, antimicrobial, antiviral, anti-allergic, in vitro antioxidant and hepatoprotective activity. The latter was further supported by an in vivo study together with an in vivo study of its antidiabetic activity.
Chapter (3): A preliminary phytochemical screening of Eremophila maculata leaves followed by an in-depth phytochemical study of its methanol extract was done. Further chromatographic separation was carried out to characterize and isolate the relevant compounds that may be responsible for the biological activity. Moreover, LC-MS run was done on the methanol extract with the aim to tentatively identify its chief active constituents.
Chapter (4): A comprehensive study was performed on the essential oils of Eremophila maculata leaf, flower, fresh and air-dried stems with the target to explore their chemical
Other data
| Title | PHYTOCHEMICAL AND BIOLOGICAL STUDY ON CERTAIN PLANTS BELONGING TO FAMILY SCROPHULARIACEAE | Other Titles | دراسة فيتوكيميائية وبيولوجية لبعض النباتات التي تنتمي للعائلة السكروفولاريسية | Authors | Fadia Salah Youssef | Issue Date | 2014 |
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