Role of leptin in development of liver fibrosis in metabolic syndrome with hepatic steatosis

Abstract

The metabolic syndrome (MetS) is a complex of interrelated risk factors for cardiovascular disease (CVD) and diabetes; these factors include dysglycemia, raised blood pressure, elevated triglyceride levels, low high-density lipoprotein cholesterol levels, and obesity (particularly central adiposity), insulin resistance has been focused as a linking factor, the prevalence of metabolic syndrome increases with increasing glucose intolerance and with the increasing world wide prevalence of DM. An increasing number of clinical and experimental studies suggest that inflammatory mechanisms are important in the pathogenesis of type 2 diabetes. For example, it has been shown that in obese and type 2 diabetic human subjects, adipocytes secrete increasing levels of chemokines as, leptin and IL-6 compared to lean controls, altered production and secretion of several adipocytokines may be concerned with the pathogenesis of metabolic syndrome, as is suggested by some studies