Development and Evaluation of Some New Disperse Drug Delivery Systems Using Nanotechnology
Yosra Shaaban Rabea Elnaggar;
Abstract
This thesis is highlighting focus on two vital drugs in treatment of breast cancer (tamoxifen citrate) and erectile dysfimction (sildenafil citrate). Both drugs are first line choice, yet suffering from obstacles in oral delivery. The current thesis investigated relevance of nanomedicine to improve the characteristics of the two drugs via incorporation into four different nanocarriers. The work in the current thesis is divided into two parts:
Part one
Self•nanoemulsifying Drug Delivery Systems of Tamoxifen Citrate: Design and Optimization.
In the current part, tamoxifen citrate self-nanoemulsifying drug delivery systems were prepared in attempt to circumvent oral delivery handicaps. Preliminary screening was carried out to select proper surfactant, co-surfactant and oily phase. All surfactants screened were recognized for their bioactive aspects. Ternary phase diagrams were constructed and an optimum system was designated. Three tamoxifen self nanoemulsifying drug delivery systems were then compared for optimization. The systems were assessed for robustness to dilution, globule size, cloud point, surface morphology and drug release. An optimum system composed of tamoxifen citrate (1.6
%), Maisine 35-1 (16.4%), Caproyl 90 (32.8%), Cremophor RH40 (32.8%) and propylene glycol (16.4 %) was selected. The system was robust to different dilution volumes and types. It possessed a mean globule size of 150 nm and a cloud point of 80
°C. Transmission electron microscopy demonstrated spherical particle morphology. The
drug release from the selected formulation was significantly higher than other self nanoemulsifying systems and drug suspension, as well. Realizing drug incorporation into optimized nano-sized nanomedicine that encompasses a bioactive,surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate.
Part two
Implications ofNanotechnology for Sildenafil Citrate Therapy
Sildenafil citrate is considered a mainstay in treatment of erectile dysfimction. However,, the oral delivery encounters many obstacles. These include extensive first pass metabolism, numerous side effects and relatively short duration. Furthermore, the physicochemical characteristics of this amphoteric drug are challenging for delivery system formulation. Part two Of this thesis exploited nanomedicine to prepare and assess sildenafil citrate nanocarriers conspire to improve drug characteristics and therapeutic performance. Part two is sub-classified into three chapters, as follows:
Part one
Self•nanoemulsifying Drug Delivery Systems of Tamoxifen Citrate: Design and Optimization.
In the current part, tamoxifen citrate self-nanoemulsifying drug delivery systems were prepared in attempt to circumvent oral delivery handicaps. Preliminary screening was carried out to select proper surfactant, co-surfactant and oily phase. All surfactants screened were recognized for their bioactive aspects. Ternary phase diagrams were constructed and an optimum system was designated. Three tamoxifen self nanoemulsifying drug delivery systems were then compared for optimization. The systems were assessed for robustness to dilution, globule size, cloud point, surface morphology and drug release. An optimum system composed of tamoxifen citrate (1.6
%), Maisine 35-1 (16.4%), Caproyl 90 (32.8%), Cremophor RH40 (32.8%) and propylene glycol (16.4 %) was selected. The system was robust to different dilution volumes and types. It possessed a mean globule size of 150 nm and a cloud point of 80
°C. Transmission electron microscopy demonstrated spherical particle morphology. The
drug release from the selected formulation was significantly higher than other self nanoemulsifying systems and drug suspension, as well. Realizing drug incorporation into optimized nano-sized nanomedicine that encompasses a bioactive,surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate.
Part two
Implications ofNanotechnology for Sildenafil Citrate Therapy
Sildenafil citrate is considered a mainstay in treatment of erectile dysfimction. However,, the oral delivery encounters many obstacles. These include extensive first pass metabolism, numerous side effects and relatively short duration. Furthermore, the physicochemical characteristics of this amphoteric drug are challenging for delivery system formulation. Part two Of this thesis exploited nanomedicine to prepare and assess sildenafil citrate nanocarriers conspire to improve drug characteristics and therapeutic performance. Part two is sub-classified into three chapters, as follows:
Other data
| Title | Development and Evaluation of Some New Disperse Drug Delivery Systems Using Nanotechnology | Other Titles | تطوير وتقويم بعض الانظمة الانتشارية الجديدة لتوصيل الدواء باستخدام تقنية الناتو | Authors | Yosra Shaaban Rabea Elnaggar | Issue Date | 2010 |
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