CD 47 Assessment In Immune Thrombocytopenic Purpura
Nour Elhuda Hussien Abdalla;
Abstract
CD47 is a cell surface protein of the immunoglobulin
(Ig) superfamily, which is heavily glycosylated and expressed
by virtually all cells in the body. CD47 was first recognized as
a 50 kDa protein associated and copurified with the integrin in
placenta and Europhile granulocytes.
Platelet homeostasis is regulated by platelet expression
of CD47 under normal conditions and in a mouse model of
immune thrombocytopenia. Interaction between platelet CD47
and macrophage SIRPa is important in regulating normal
platelet turnover and Fcg receptor mediated clearance of IgGsensitized
platelets. CD47- deficient platelets have a shortened
half-life in the circulation of CD47 wild-type mice and are also
more sensitive to Fcg receptor mediated clearance.CD47- and
SIRPa-deficient mice are thrombocytopenic due to an
increased rate of clearance of circulating platelets.
In the present study CD47 was measured in100 subjects
that grouped into:
Group-I: included 30 adult patients diagnosed chronic nonresponder
ITP.
Group-II: included 30 adult patients diagnosed chronic
responder ITP.
Group-III: included 30 adult patients newly diagnosed ITP.
Group-IV: included 10 sex and age matched healthy controls
subjects.
In our study the
(Ig) superfamily, which is heavily glycosylated and expressed
by virtually all cells in the body. CD47 was first recognized as
a 50 kDa protein associated and copurified with the integrin in
placenta and Europhile granulocytes.
Platelet homeostasis is regulated by platelet expression
of CD47 under normal conditions and in a mouse model of
immune thrombocytopenia. Interaction between platelet CD47
and macrophage SIRPa is important in regulating normal
platelet turnover and Fcg receptor mediated clearance of IgGsensitized
platelets. CD47- deficient platelets have a shortened
half-life in the circulation of CD47 wild-type mice and are also
more sensitive to Fcg receptor mediated clearance.CD47- and
SIRPa-deficient mice are thrombocytopenic due to an
increased rate of clearance of circulating platelets.
In the present study CD47 was measured in100 subjects
that grouped into:
Group-I: included 30 adult patients diagnosed chronic nonresponder
ITP.
Group-II: included 30 adult patients diagnosed chronic
responder ITP.
Group-III: included 30 adult patients newly diagnosed ITP.
Group-IV: included 10 sex and age matched healthy controls
subjects.
In our study the
Other data
| Title | CD 47 Assessment In Immune Thrombocytopenic Purpura | Authors | Nour Elhuda Hussien Abdalla | Issue Date | 2014 |
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