Value of Plasma Alpha L Fucosidase Level as A prognostic Biomarker for Hepatocellular Carcinoma before and after Chemo-embolization and Radio-frequency
Radwan Mohamed Radwan;
Abstract
he aim of this study was to assess the value of alpha L fucosidase as a prognostic biomarker in patients with HCC before and after chemo-embolization and radio-frequency.
The study was conducted upon 60 subjects who were divided into 3 groups:
Group 1: 30 patients with HCC
Group 2: 20 patients with liver cirrhosis
Group 3: 10 healthy subjects as controls
Patients with HCC were diagnosed by Triphasic CT imaging showing arterial uptake followed by washout which is highly specific for HCC or AFP > 200.
Patients with liver cirrhosis were diagnosed by lab. Investigations and U/S.
In this study the age of the patients ranged between 47-61 years, Child-Pugh score was higher in liver cirrhotic group than HCC group due to the inclusion criteria of doing TACE or RF.
Regarding AFP, its serum levels were highest in HCC group compared to the other groups with significant difference.
Regarding AFU, its serum levels were much higher in the HCC group compared to the other groups with significant difference, although it didn’t correlate with other laboratory investigations or AFP.
At a cut off value > 2.5, the diagnostic sensitivity and specificity of AFU for selective detection of HCC over the cirrhotic group was 100% and 95% respectively. Meanwhile At a cut off value > 6, the diagnostic sensitivity and specificity of AFP for selective detection of HCC over the cirrhotic group was 93.3% and 70% respectively.
It was shown that the Basal AFU had significantly high diagnostic performance in predicting the diagnosis of failure of treatment at cut off value of >12.5 with sensitivity 100% and specificity was 92%. While AFU after intervention had significant moderate performance in predicting the diagnosis of recurrence at cut off value of > 7.5 with sensitivity 80% and specificity was 92%.
After intervention, AFU
The study was conducted upon 60 subjects who were divided into 3 groups:
Group 1: 30 patients with HCC
Group 2: 20 patients with liver cirrhosis
Group 3: 10 healthy subjects as controls
Patients with HCC were diagnosed by Triphasic CT imaging showing arterial uptake followed by washout which is highly specific for HCC or AFP > 200.
Patients with liver cirrhosis were diagnosed by lab. Investigations and U/S.
In this study the age of the patients ranged between 47-61 years, Child-Pugh score was higher in liver cirrhotic group than HCC group due to the inclusion criteria of doing TACE or RF.
Regarding AFP, its serum levels were highest in HCC group compared to the other groups with significant difference.
Regarding AFU, its serum levels were much higher in the HCC group compared to the other groups with significant difference, although it didn’t correlate with other laboratory investigations or AFP.
At a cut off value > 2.5, the diagnostic sensitivity and specificity of AFU for selective detection of HCC over the cirrhotic group was 100% and 95% respectively. Meanwhile At a cut off value > 6, the diagnostic sensitivity and specificity of AFP for selective detection of HCC over the cirrhotic group was 93.3% and 70% respectively.
It was shown that the Basal AFU had significantly high diagnostic performance in predicting the diagnosis of failure of treatment at cut off value of >12.5 with sensitivity 100% and specificity was 92%. While AFU after intervention had significant moderate performance in predicting the diagnosis of recurrence at cut off value of > 7.5 with sensitivity 80% and specificity was 92%.
After intervention, AFU
Other data
| Title | Value of Plasma Alpha L Fucosidase Level as A prognostic Biomarker for Hepatocellular Carcinoma before and after Chemo-embolization and Radio-frequency | Authors | Radwan Mohamed Radwan | Issue Date | 2018 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.