Ischemia Modified Albumin as a Marker of Oxidative Stress in Infants of Diabetic Mother: Relation to Lipid Peroxidation and Maternal Glycemic Control

Abstract

SUMMARY O xidative stress can play an important role in the pathogenesis of DM, GDM and in the development of maternal and fetal complications of diabetic pregnancies. Ischemia modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress. It has been suggested that elevated levels of IMA may reflect a generalized rather than organ- or tissue-specific state of oxidative stress. Few studies investigated the role of IMA as a marker of maternal-fetal oxidative stress in diabetic mothers and their infants and its possible relation to lipid peroxidation and antioxidant status including essential trace elements among those infants remains to be elucidated. The aim of study was to evaluate oxidant-antioxidant balance in infants of diabetic mothers by measuring total antioxidant capacity (TAC) and malondialdehyde (MDA) as well as IMA. Moreover, we assessed the relation between IMA and clinical and laboratory characteristics including lipid peroxidation, total anti-oxidant status, essential trace elements and glycemic control of mothers. This study comprised 100 full term neonates delivered at Obstetrics and Gynecology hospital, Ain Shams University during the period from January 2017 to April 2017; 50 inf