HISTOPATHOLOGIC STUDY AND IMMUNOHISTOCHEMICAL EVALUATION OF P53 AND Ki-67 ANTIGENS EXPRESSION IN THYROID NEOPLASMS

Abstract

Common thyroid neoplasms present as thyroid nodules, arld 90% of neoplastic nodules are adenomas Thyroid carcinomas are relatively uncommon, accounting for about 1.5% of all cancers. I '

I The purpose of the present study was to analyze a variety cJ>f human thyroid tumors for the presence of p53 and Ki-67 antigen expression using the EnVision technique on formalin-fixed!, I paraffin embedded tissue sections. Results of staining for p53 and

Ki-67 antigens were correlated with tumor types, tumor I differentiation and tumor size.

I Sixty specimens from patients with primary thyroid

neoplasms were available for this study. The cases were collected from the pathology department, Kasr EL- Aini Hospital and private laboratories in the period between November 1999 to December 2000. The cases were classified as benign and maligna t

according to the WHO classification (Hedinger et al., 1989). I I Benign cases were15 follicular adenoma. Malignant cases were 45, including 35 cases of well differentiated carcinoma (30 papillary and 5 follicular carcinoma), 4 poorly differentiateb I carcinoma, 3 undifferentiated carcinoma, and 3 medullary

carcinoma.