“Effect of Bone Marrow Derived Mesenchymal Stem Cells infusion Timing on Radiation Induced Oral Mucositis in Albino rat”

Abstract

Summary Mucositis induced by radiotherapy is defined as the reactive inflammation of the oral and oropharyngeal mucous membrane during radiotherapy in the head and neck region. It is characterized by atrophy of squamous epithelial tissue, absence of vascular damage, and an inflammatory infiltrate concentrated at the basement membrane. Oral Mucositis is considered one of oral side effects that develop early during radiotherapy. Given the regenerative and anti-inflammatory properties of stem cells; the current work aimed to investigate the effect of intravenous infusion of bone marrow derived mesenchymal stem cells (BM-MSCS) before or after head and neck radiation in ameliorating the side effects of ionizing radiation.