Assessment of Klotho Protein and Fibroblast Growth Factor -23 on the Progression of Atherosclerosis in Vitamin D Deficient Egyptian Patients

Abstract

Cardiovascular diseases are the leading cause of death in the world. In Egypt, as in many other parts of the world, atherosclerosis and heart diseases are spread between the populations. Hypertension, diabetes, high cholesterol, smoking, lack of exercise and genetic factors are the leading causes of heart diseases in Egypt. Early plaque formation is one of the key risk factors for patients, which is often linked with genetic predisposition to heart diseases. Cutting the bad habits, introducing new healthy habits can help minimize the risk of heart diseases. The objective of this study was to investigate the sensitivity and specificity of some biochemical parameters such as plasma FGF-23, klotho protein, IL-17, rennin, serum NO, calcium, phosphorus, lipid parameters including TAG, TC and HDL-c in VDD and VDI patient groups. To fulfill the target of the present study, a total of 40 male patients with coronary artery disease of age range (40-60 years) were included. The patients were selected by the physician from the Cardiology Department El-Demerdash hospital, Ain- Shams University. Also 15 normal controls age matched were selec