New dietary factors implicated in the pathophysiology of microvascular complications in type 1 diabetes mellitus

Abstract

The present work is a study on type 1 diabetic children and adolescents to show the status of homocysteine and fatty acids status, and their relation to presence of diabetic micro­ vascular complications, and to define the relationship between micro-vascular complications in type 1 DM and different factors including, disease duration, BMI, blood pressure, dietary protein intake, the degree of glycemic control, plasma homocysteine and fatty acids was also studied. The present study included 50 patients with type 1 diabetes, 32 without micro-vascular complications (MVC), and 18 with (MVC). These were compared to a group of 20 healthy age and sex-matched subjects. All patients and controls were subjected to Full history taking, clinical examination, and laboratory investigations including complete urine analysis, creatinine clearance, urinary albumin excretion, blood glucose level, glycosylated hemoglobin (HbAlc), homocysteine plasma level and fatty acid analysis. Results of the present work revealed diabetic patients with MVC (group B) had significantly longer mean disease