Vascular dysfunction and its impact on coagulopathy in adult Egyptian thalassemic patients

Abstract

This study aimed to clarify and update the role of endothelial dysfunction and Monocytes among adolescents with transfusion dependant β- thalassemic patients using von Willebrand factor antigen (VWF:Ag) and flow cytometric analysis of circulating CD14 monocyic Micropartiles (mMps) and CD11b for monocytes activation and assess their relation to hypercoagulopathy and thrombosis in these patients.This study showed that VWF Ag was higher in patients than controls and was positively correlated to thrombotic events in thalassemic patients,.There was no significance difference for CD14 between patients and controls and CD11b was higher in controls.Additionally, splenectomized patients had positive correlation with thrombosis. Iron overload caused monocytic dysfunction that could participate in decresed CD11b level and affected its role in blood coagulation. Key Words: Endothelial dysfunction, Monocytes, β- thalassemic, VWF: Ag, CD14, CD11b, thrombosis