Implication of Flow Cytometry-Based Maturity Score in Risk Stratification of Acute Myeloid Leukemia In Adult Egyptians
Esraa Adel Mahmoud El Debaky;
Abstract
A
cute myeloid leukemia (AML) is a clonal hematopoietic stem cell disorder, characterized by arrested differentiation, inappropriate proliferation and survival of immature myeloid progenitors. The AML has the lowest survival rate of all leukemias, so, assessment of the prognostic factors in AML is very important.
This work aimed to determine the influence of immune-phenotypic maturity, via application of the flow cyto-metric maturity score based on quantitative expression of the three markers of maturity; CD34, CD117, TdT with a score from 0 to 5, on laboratory parameters, clinical outcome and survival of patients with acute myeloid leukemia within the different cytogenetic risk groups.
cute myeloid leukemia (AML) is a clonal hematopoietic stem cell disorder, characterized by arrested differentiation, inappropriate proliferation and survival of immature myeloid progenitors. The AML has the lowest survival rate of all leukemias, so, assessment of the prognostic factors in AML is very important.
This work aimed to determine the influence of immune-phenotypic maturity, via application of the flow cyto-metric maturity score based on quantitative expression of the three markers of maturity; CD34, CD117, TdT with a score from 0 to 5, on laboratory parameters, clinical outcome and survival of patients with acute myeloid leukemia within the different cytogenetic risk groups.
Other data
| Title | Implication of Flow Cytometry-Based Maturity Score in Risk Stratification of Acute Myeloid Leukemia In Adult Egyptians | Other Titles | تضمين معيار النضج بواسطة التدفق الخلوي في تحديد درجة خطورة الابيضاض النخاعي الحاد في المصريين البالغين | Authors | Esraa Adel Mahmoud El Debaky | Issue Date | 2018 |
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