The study of Mean Platelet Volume (MPV) as a Potential Risk Factor for Macrovascular Complications (Ischemic Heart Disease and Cerebrovascular Stroke) in Type 2 Diabetes Mellitus

Abstract

ype 2 diabetes mellitus (T2DM) has reached global epidemic proportions, with more than 382 million people affected according to a 2013 estimate. By 2035, its prevalence is expected to reach 471 million, meaning that 10% of the world’s population will have diabetes. Patients with diabetes often suffer from metabolic abnormalities, poor glycemic control, oxidative stress, insulin resistance, and low-grade inflammation. These conditions trigger vascular dysfunction, which predisposes them to atherothrombosis. The coronary risks associated with T2DM are similar to those of nondiabetic patients with previous myocardial infarction (MI). Diabetes almost doubles the risk of having a stroke. This is because high levels of glucose in blood can damage the blood vessels, making them harder and narrower and more likely to become blocked. If this happens in the cerebral blood vessels it could cause a stroke .