Anticancer effect of Cerastes vipera venom on cancer cell line HepG-2
Aalaa Adel Mostafa Mohamed Elmeligy;
Abstract
Abstract
Snake venoms are mixtures of bioactive proteins, peptides and enzymes that stimulate diverse biochemical activities and that made them attractive sources for research into potentially novel therapeutics. In the current study, Cerastes vipera crude venom was chosen to study its efficiency in inducing significant cytotoxicity to cancer cell line HepG-2. We performed a cytotoxicity test, morphological studies by using inverted microscope, transmission electron microscope (TEM) investigations and biochemical analyses by estimating the levels of glutathione reduced (GSH), lipid peroxide/malondialdehyde (MDA) and total antioxidant capacity (TAC) to examine cytotoxic effects of different concentrations of Cerastes vipera crude venom toward the cancer cell line HepG-2 at different time intervals.
Snake venoms are mixtures of bioactive proteins, peptides and enzymes that stimulate diverse biochemical activities and that made them attractive sources for research into potentially novel therapeutics. In the current study, Cerastes vipera crude venom was chosen to study its efficiency in inducing significant cytotoxicity to cancer cell line HepG-2. We performed a cytotoxicity test, morphological studies by using inverted microscope, transmission electron microscope (TEM) investigations and biochemical analyses by estimating the levels of glutathione reduced (GSH), lipid peroxide/malondialdehyde (MDA) and total antioxidant capacity (TAC) to examine cytotoxic effects of different concentrations of Cerastes vipera crude venom toward the cancer cell line HepG-2 at different time intervals.
Other data
| Title | Anticancer effect of Cerastes vipera venom on cancer cell line HepG-2 | Other Titles | التأثير المضاد للسرطان لسم سيراستس ڨيبيرا على خط خلايا الكبد HepG-2 السرطانية | Authors | Aalaa Adel Mostafa Mohamed Elmeligy | Issue Date | 2018 |
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