Evaluation of Serum Neurotensin Level in Fatty Diet Induced Obesity

Abstract

Very recently, the World Obesity Federation argued that ‗obesity was considered as a chronic, relapsing, progressive, disease process‘ that requires intervention (Bray et al.,2017). Obesity is a complex chronic disorder with a multifactorial etiology involving genetics, hormones, diets, and environments (Kollias and Sfikakis., 2010). Neurotensin is expressed in the brain as well as it is localized in specialized enteroendocrine cells of the small intestine (Ratner et al., 2016). Recent work reporting that Neurotensin deficient mice are protected against diet-induced obesity. The findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment (LI et al., 2016). The aim of the work was to evaluate the serum level of neurotensin in various grades of obesity and it's relation to fatty diet. We conducted our study on 60 obese patients in addition to 25 normal weight persons who are serving as a control group.