STUDY OF THE POLYMORPHISM BsmI AND TaqI IN VITAMIN D RECEPTOR GENE IN EGYPTIAN PATIENTS WITH CHRONIC KIDNEY DISEASE

Abstract

hronic kidney disease is one of the most problematic diseases in our country, a leading cause of morbidity and mortality worldwide. Chronic kidney disease-mineral and bone disease is a common complication of CKD and an important cause of morbidity and decreased life quality. It comprises a group of inter-related abnormalities of either one or a combination of the following: i) serum bone biomarkers: calcium, phosphorus, parathyroid hormone or vitamin D metabolism, ii) bone: bone turnover, mineralization, volume, linear growth or strength and iii) the vasculature: arterial stiffness and calcification. Serum levels of 25-hydroxy vitamin D and iPTH provide an accurate picture of bone turnover and mineralization states therefore they could be used with other serum bone biomarkers as non-invasive sensitive bone markers to help management of MBD in CKD patients.