Subfoveal Choroidal Thickness Measurement by Swept Source OCT in Retinitis Pegmentosa Patients

Abstract

etinitis pigmentosa (RP) is a group of hereditary retinal diseases that result in progressive loss of rod and cone photoreceptors. It occurs in approximately one in 4000 individuals, with a worldwide prevalence of 1.5 million affected individuals. The inheritance of RP is variable, with autosomal dominant, autosomal recessive, X-linked and sporadic cases. There is variable clinical presentation with a wide range of severity, age of onset, progression and other phenotypic features. Common clinical features of RP include night blindness, progressive loss of peripheral visual field with eventual loss of central vision, and characteristic retinal pigmentary changes that have a bone spicule-like appearance. Other findings include depigmentation of the retinal pigment epithelium (RPE), waxy pallor of the optic nerve, loss of photoreceptors and attenuated retinal vasculature. Electroretinograms are often reduced in amplitude in patients with advanced RP.