The Potential Hepatoprotective Effect of Quercetin on Cholestatic Liver Injury in Rats

Abstract

This study was planned to investigate the possible protective effect of quercetin and the underlying mechanisms on cholestatic liver injury induced by bile duct ligation in rats. The present work was carried out on 30 adult male albino rats weighing 150-250 grams which were divided into three groups: Sham-operated group (SHAM, n=11): Rats in this group underwent all steps of surgical procedure like that of bile duct ligation group except ligation of bile duct and received distilled water daily in a dose of 1ml/Kg by gavage, starting from the 4th day of operation till the 28th day. Bile duct-ligated group (BDL, n=9): Rats in this group underwent bile duct ligation and received distilled water daily in a dose of 1 ml/Kg by gavage, starting from the 4th day of operation till the 28th day.