Prevalence of Plasma Cell Free DNA and its Prognostic Role in Systemic Lupus Erythematous Patients
Karim Mohamed Saeed Elshourbagy;
Abstract
ABSTRACT
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with a complex pathogenesis involving multiple genetic and environmental factors. The clinical course of lupus disease usually occurs in exacerbation and remission pattern. It may involve virtually any organ and have a wide range of disease severity. Cell death has been regarded as an important event in lupus pathogenesis as it leads to release of antigens as nucleic acid for immune complex formation that leads to detrimental effects causing manifestations of SLE. The aim of this study was to estimate cf-DNA as diagnostic and prognostic marker in SLE patients in correlation with anti-double stranded DNA. 75 SLE patients were chosen from rheumatology department Ain shams university hospitals and were subjected to full rheumatological and laboratory investigations.
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with a complex pathogenesis involving multiple genetic and environmental factors. The clinical course of lupus disease usually occurs in exacerbation and remission pattern. It may involve virtually any organ and have a wide range of disease severity. Cell death has been regarded as an important event in lupus pathogenesis as it leads to release of antigens as nucleic acid for immune complex formation that leads to detrimental effects causing manifestations of SLE. The aim of this study was to estimate cf-DNA as diagnostic and prognostic marker in SLE patients in correlation with anti-double stranded DNA. 75 SLE patients were chosen from rheumatology department Ain shams university hospitals and were subjected to full rheumatological and laboratory investigations.
Other data
| Title | Prevalence of Plasma Cell Free DNA and its Prognostic Role in Systemic Lupus Erythematous Patients | Other Titles | انتشار الحمض النووي الحر في البلازما في مرضى الذئبة الحمراء | Authors | Karim Mohamed Saeed Elshourbagy | Issue Date | 2019 |
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