Study of Markers of Oxidative Stress and Reducing Substance during the Course of Diabetic Ketoacidosis in Diabetic Children and Adolescents

Abstract

iabetes mellitus is one of the most common metabolic disorders among the pediatric age group. Diabetic ketoacidosis is a very common, and a potentially life threatening complication of diabetes mellitus type 1. Also, it should be noted that the hallmark of diabetes mellitus which is chronic hyperglycemia elicits the production of reactive oxygen species. The correlation between G6PD deficiency and diabetes has been previously reported. Also, it has been noticed that hemolysis that occurs in patients with G6PD deficiency and diabetes at the same time, usually presents in the setting of diabetic ketoacidosis. Interestingly, these reported attacks of hemolysis usually occurred after correction of the diabetic ketoacidosis. The main aim of our study is to assess whether the peak of oxidant stress in type 1 diabetic children and adolescents is at presentation in DKA, or if it occurs during resolution of diabetic ketoacidosis. Our study included 40 diabetic patients, and 10 controls age and sex matched in the pediatric hospital, faculty of medicine, Ain shams University. The patients included in the study were subjected to full history taking; thorough clinical examination laying stress on