The Protective Effect of Moringa oleifera Extract and Hepatoprotective Remedy Against Sodium Valproateinduced Liver Toxicity in Adult Rats

Abstract

Epilepsy is not a disease, but a syndrome of different cerebral disorders of the Central Nervous System (CNS) which is characterized by excessive discharges of large numbers of neurons. It is a common neurological disorder worldwide. Valproate (VPA) is a widely used drug for treatment of epileptic seizures. Hepatic toxicity is a hallmark adverse reaction to sodium valproate (VPA). The present study was designed to explore the hepatoprotective efficacy of Moringa oleifera leaves extract on liver toxicity induced by sodium valproate in adult rats. A number of Adult Sprague-Dawley rats weighing (120- 150 g) were used. The animals were divided into five groups, each with 24 animals, 8 rats per cage as in the following design: Group1 :(Control) group received 1ml/100 g b.wt of vehicle (2% tween 80 in water) daily. Group 2 (VPA): Sodium valproate- treated group in which the rats were treated orally with sodium valproate