Potential modulatory effect of cranberry powder extract in experimental model of fatty liver in rats

Abstract

The present study was directed to investigate for the first time the possible anti-fibrotic effect of cranberry nutraceutical in a model of high fat diet-induced NAFLD and liver fibrosis in rats. Moreover, the possible underlying mechanisms were clarified via studying, different oxidative, inflammatory markers as well as insulin sensitivity and signaling. In this study, fifty rats were divided randomly into five groups. • Group (1): rats were fed normal rat chow diet for eight weeks and received 1ml/kg distilled water orally 3 times weekly and is considered the control group. • Group (2): rats were fed HFCD for eight weeks and received 1ml/kg distilled water orally 3 times weekly for eight weeks and was considered the HFCD group. • Group (3): rats were fed HFCD for eight weeks and received CE (50mg/kg) orally 3 times weekly for eight weeks and was considered the CE 50/HFCD treated group. • Group (4): rats were fed HFCD for eight weeks and received CE (100mg/kg) orally 3 times weekly for eight weeks and was considered the CE100 /HFCD treated group. • Group (5): rats were fed normal rat chow diet and received CE (100mg/kg/) orally 3 times weekly for eight weeks and was considered the CE100 treated group. Afterwards, blood samples were collected, then animals of all groups were sacrificed and liver tissues were dissected out for further analysis.