Evaluation of Cactus and/or Papaya Juices Administration on Neuro, Hepatic and Renal Toxicity and Subfertility Induced by Chlorpyrifos in Rats

Abstract

The aim of the present study was to identify the bioactive components in cactus and papaya juices by GC-MS analysis. Moreover, to determine their effects on biological and biochemical parameters as well as microscopic examination on the alleviation of brain, liver, kidneys and testes cytotoxicity induced by chlorpyrifos in rats. Sixty male albino rats Sprague-Dawley strain were divided into 5 groups each of 12 rats. First group was left as control group. Second group was given chlorpyrifos 6 mg/kg b. wt. The other three groups were given cactus, papaya juices and mixture of them as 20 ml/kg b. wt., subsequently along with chlorpyrifos dose. All doses were orally administered daily for 28 successive days. At the end of the experimental period, blood samples, brain, liver, kidneys and testes were collected from each rat for biochemical analysis and microscopic examination.