.Assessment of Different Regiment of Progesterone Administration In Luteal Phase Support In IVF Cycles

Abstract

In induced IVF cycles, the use of OnRil agonists and the removal of granulosa cells during aspiration of the oocyte can lead to a relative P deficit and inappropriate preparation of the endometrium for implantation of an embryo and survival of pregnancy. The use of GnRH agonists in ovarian Stimulation which prevents a premature surge of LH, ultimately leads to suppression of the pituitary gland, thereby blocking the secretion of LH at least 10 days following the last applied GnRH dose, as well as the pulsatile secretion of P. In addition, high levels of estrogen observed during induced cycles result in an inhibiting effect on the implantation of human embryos. The use of pharmaceutical luteal support to reach the physiological ratio of estrogen to P could only be beneficial.