Epigenetic modification and antioxidant activity of sulforaphane and selenium nanoparticles against brain metabolic dysfunctions leading to Alzheimer's disease in rats

Abstract

Abstract In recent years, the incidental rate of neurodegenerative diseases (NDs), in general, and Alzheimer’s disease (AD) in particular, has increased proportionately with the aging population. These diseases are multifactorial and their current treatment strategies are only associated with symptomatic relief rather than curbing their progression. Phytochemicals have been consistently proposed as alternative therapy in modern medicine, but their efficacy in NDs is somewhat limited by the rapid metabolism, insufficient permeability across the BBB, and decreased bioavailability and stability in the brain. Fortunately, current advances in nanotechnology present opportunities to overcome such limitations in delivering active phytochemicals candidates.