Influence of Stem Cells on Leukemogenesis Induced by 7, 12 Dimethyl Benz [a] Anthracene or Gamma Irradiation in Rats
Esraa Samir Abdel Aty Ahmed;
Abstract
Abstract
Mesenchymal stem cells (MSCs) are a promising source for cell therapy in regenerative medicine. Accordingly, the aim of the present study is to evaluate the potential effect of MSCs transplantation against leukemogenesis in rats. This aim was achieved by measuring inflammatory indices, chemokine, apoptotic markers and signaling growth factors.
The obtained results showed that MSCs transplantation enhance hematological parameters, alleviat bone marrow oxidative markers and inflammatory indices (TGF-β and IL-6). Additionally, MSCs transplantation increased the homing efficacy of hematopoietic stem cells to bone marrow throughout upregulation of CXCR-4 expression. Moreover, treatment with MSCs, modulate apoptosis/proliferation of bone marrow cells, the growth factors and signaling pathway that encounters bone marrow damage.
Mesenchymal stem cells (MSCs) are a promising source for cell therapy in regenerative medicine. Accordingly, the aim of the present study is to evaluate the potential effect of MSCs transplantation against leukemogenesis in rats. This aim was achieved by measuring inflammatory indices, chemokine, apoptotic markers and signaling growth factors.
The obtained results showed that MSCs transplantation enhance hematological parameters, alleviat bone marrow oxidative markers and inflammatory indices (TGF-β and IL-6). Additionally, MSCs transplantation increased the homing efficacy of hematopoietic stem cells to bone marrow throughout upregulation of CXCR-4 expression. Moreover, treatment with MSCs, modulate apoptosis/proliferation of bone marrow cells, the growth factors and signaling pathway that encounters bone marrow damage.
Other data
| Title | Influence of Stem Cells on Leukemogenesis Induced by 7, 12 Dimethyl Benz [a] Anthracene or Gamma Irradiation in Rats | Other Titles | تأثير الخلايا الجذعية على سرطان الدم المستحث بواسطة ٧ و ١٢ ثنائى ميثيل بنز ]أ[ انثراسين أوأشعة جاما فى الجرذان | Authors | Esraa Samir Abdel Aty Ahmed | Issue Date | 2019 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| CC2156.pdf | 1.84 MB | Adobe PDF | View/Open |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.