The Role of Bcl-2 in Pediatric Functional Bowel Obstruction Cases with Ganglionated Specimens

Abstract

P ediatric motility disorders constitute a complex array of clinicopathologic disturbances (Feichter et al., 2010). Intestinal pseudo-obstruction is a disorder characterised by the inability of the gastrointestinal tract to propel its contents mimicking mechanical obstruction, in the absence of any lesion occluding the gut (Thapar et al., 2018). It may affect various components of the bowel neuromuscular apparatus (Jain, 2015). It is a rare disease with scant epidemiological data (Thapar et al., 2018). Congenital intestinal neuronal abnormalities have been classified as aganglionosis (Hirschsprung’s disease), hyperganglionosis, hypoganglionosis, ganglion cell immaturity, combined forms and certain unclassifiable forms (Henna et al., 2011).