Critical illness myopathy in intensive care setting

Abstract

The Aim of this work is to provide cumulative data about the efficacy and safety of neuro-muscular electrical stimulation (NMES) combined with usual care (UC) versus usual care alone in ICU patients with critical illness myopathy (CIM). The included studies published between 2009 and 2019. The total number of patients in all the included studies was 1259 patients; 652 in NMES group, and 607 in UC group. Our data were divided into two groups: NMES (652 patients), and UC (607 patients). Meta-analysis study was done on 11 studies which described and compared the 2 different techniques for treatment of CIM; with overall number of patients (N= 1259). We calculated efficacy for each technique through MRC scale (muscle strength scale), ICU stay and SF-36 scale (quality of life scale). We calculated safety for each technique through CIM incidence and mortality rate. Regarding 1ry outcome measures, we found 8 studies reported MRC scale for muscle strength, with total number of patients (N=968). The random-effects model of the meta-analysis study showed non-significant difference in mean MRC scale in NMES group compared to usual care group (p > 0.05).