PLACENTAL APOPTOSIS IN PRE-ECLAMPSIA
Waleed Mamdouh EI-Khayat;
Abstract
Pre-eclampsia is a major cause of maternal and fetal morbidity.
The molecular mechanisms of apoptosis in humans are complex and . involve an ever-expanding . list of signaling molecules.
In human pregnancy, Bcl-2 has been immunolocalized to the syncytiotrophoblast of the chorionic villi, persists from the first to the third trimester of pregnancy and decreases as gestation progresses, suggesting an effect on normal aging of the placenta.
The aim of this study is to determine whether there is an increase in placental apoptosis in pregnancies complicated by pre-eclampsia compared with placentas from normal pregnancy and whether immune regulators of apoptosis such as Bcl-2 are differently expressed.
Placental samples from 40 pre-eclamptic women and 20 normotensive control were assessed for apoptotic nuclear changes by using light microscope and immunohistochemical staining of Bcl-2 also was done.
It was found that there was an increase m trophoblast apoptosis in placentas from women with pregnancies complicated by pre-eclampsia compared with controls with no differences in the expression of Bcl-2 within placental tissue between the two groups.
The molecular mechanisms of apoptosis in humans are complex and . involve an ever-expanding . list of signaling molecules.
In human pregnancy, Bcl-2 has been immunolocalized to the syncytiotrophoblast of the chorionic villi, persists from the first to the third trimester of pregnancy and decreases as gestation progresses, suggesting an effect on normal aging of the placenta.
The aim of this study is to determine whether there is an increase in placental apoptosis in pregnancies complicated by pre-eclampsia compared with placentas from normal pregnancy and whether immune regulators of apoptosis such as Bcl-2 are differently expressed.
Placental samples from 40 pre-eclamptic women and 20 normotensive control were assessed for apoptotic nuclear changes by using light microscope and immunohistochemical staining of Bcl-2 also was done.
It was found that there was an increase m trophoblast apoptosis in placentas from women with pregnancies complicated by pre-eclampsia compared with controls with no differences in the expression of Bcl-2 within placental tissue between the two groups.
Other data
| Title | PLACENTAL APOPTOSIS IN PRE-ECLAMPSIA | Other Titles | تلاشى الخلايا المشيمية فى حالات تسمم الحمل | Authors | Waleed Mamdouh EI-Khayat | Issue Date | 2004 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B13673.pdf | 919.68 kB | Adobe PDF | View/Open |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.