An efficient synthesis and evaluation of some novel quinazolinone-pyrazole hybrids as potential antiproliferative agents
Abdelaal A. Abdalha; Mohamed Hussein Hussein Moustafa Hekal;
Abstract
A series of new quinazolinones and related compounds has been conveniently synthesized via reaction of (E)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(6-iodo-4-oxo-4H-benzo[d] [1,3] oxazin-2-yl)acrylonitrile (2) with different nitrogen nucleophiles. The structures of the prepared compounds were fully elucidated using IR, 1H-NMR, and 13C-NMR spectra. The newly synthesized compounds were tested in vitro against a panel of three human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, mammary gland breast MCF-7, and colon cancer HCT-116. Some of the tested compounds showed satisfactory activity.
Other data
| Title | An efficient synthesis and evaluation of some novel quinazolinone-pyrazole hybrids as potential antiproliferative agents | Authors | Abdelaal A. Abdalha ; Mohamed Hussein Hussein Moustafa Hekal | Keywords | Benzoxazinone; quinazolinone;3-diphenyl pyrazole;tetrazole;SPECTRAL CHARACTERIZATION;BIOLOGICAL EVALUATION;ANTITUMOR EVALUATION;antiproliferative agents;DRUGS;INHIBITION;HETEROCYCLES;DERIVATIVES | Issue Date | 2-Aug-2021 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 51 | Issue | 16 | Start page | 2498 | End page | 2509 | ISSN | 0039-7911 | DOI | 10.1080/00397911.2021.1939058 | Scopus ID | 2-s2.0-85108595963 | Web of science ID | WOS:000665653900001 |
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| An efficient synthesis and evaluation of some novel quinazolinone pyrazole hybrids as potential antiproliferative agents.pdf | 1.93 MB | Adobe PDF | Request a copy |
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