Synthesis of some modified nucleosides

Abstract

The synthesized compounds include amino and amino acids residues ,also some of the synthesized derivatives had a biological activity since it had the ability to interfere into the DNA of the cell .Such that modified nucleosides are derivatives from the normal nucleosides which had binding between tRNA and an important role in biologicel activity especially the mRNA . in They had an important role protein biosynthesis. Some of these nucleosides used as antibiotics and can be prepared in laboratory which are resemble in the structure of the nucleosides which are in it be present DNA . Also can used as antitumor, antifungs, inhibitor for virus and used as therapy for both of rheumatic arthritis and increasing uric acid blood.