Correlation of Phenotype-genotype in Egyptian patients with familial Mediterranean fever

Abstract

Familial Mediterranean fever (FMF) is the most prevalent prototype in inherited auto-inflammatory syndromes. FMF affects the ethnic groups living around the Mediterranean basin mainly Jews, Turks, Armenians, Greeks and Arabs. FMF is characterized by recurrent attacks of painful inflammation in the abdomen, chest, joints, and sterile serositis, including the pericarditis and meningitis. Also, the FMF recurrent attacks are accompanied by a fever of (38–40°C). Patients with FMF may also develop erysipelas-like erythema and less frequently amyloidosis that may affect several organs, particularly the kidney, where gradual development of nephropathic amyloidosis leading to end-stage renal failure.