Synthesis, spectral and chemical reactivity ‎studies of ruthenium complexes of flexible pyridyl ‎polydentate ligands and their ‎immobilized derivatives in solid supports

Abstract

Six new bicombartment Schiff bases were prepared via condensation of 2-benzoylpyridine, Di(2-pyridyl)ketone, 2-hydroxy-3-methoxy benzaldehyde with the diamines diethylenetriamine (Dien) and 2,2′-(ethylenedioxy)-bis-(ethylamine) (EDEA) in 2:1 molar ratio using standard synthesis methods. A new series of ruthenium(II) and ruthenium(III) complexes were also prepared and fully characterized by elemental analysis, FT-IR, 1H-NMR, UV-vis, conductivity, and magnetic susceptibility measurements. Biological activities of the synthesized ruthenium(II) complexes were investigated by studying their ability to interact with CT-DNA, antioxidant scavenging, cytotoxicity against some cancer line cells. In addition, the Ru(II) complexes were immobilized on silica surface and factors affecting their adsorption capacity such as pH, contact time and silica dose were studied.