The relationship between serum homocysteine level and cognitive function in elderly patients with chronic kidney disease

Abstract

The prevalence of chronic kidney disease is growing rapidly worldwide and the estimates of its prevalence are expected to rise (Yarnoff et al., 2018). Chronic kidney disease CKD has been associated with an increased risk of developing cognitive decline and dementia. Large prospective studies have provided strong evidence that older people with CKD are at a significantly higher risk of developing cognitive dysfunction and more importantly memory and executive function impairment (Tamura et al., 2016). This study was conducted to assess the relationship between serum homocysteine level and cognitive function in elderly patients with chronic kidney disease. A case-control study was performed on 200 elderly 60 years and older, male and female they were divided into two groups: Group 1 (case group):100 elderly subjects with chronic kidney disease CKD without Co-morbid Conditions that affect cognitive function. Group 2 (control group): 100 elderly subjects without CKD and also without Co-morbid Conditions that affect cognitive function. Both groups were recruited from outpatient clinics at Ain Shams University hospital.