The Potential Anti Breast Cancer Effect of Curcumin and Zinc Nanoparticles in Female Rats

Abstract

Cancer is an aggressive disease contributing strongly in deaths around world. Breast cancer is one of the most common causes of death in females. Although there are many breast cancer therapeutic stratigies, they either have limitations or sometimes be resisted by the cancer cells, so new approaches in that field are needed to tackle those restrictions. Nanotechnology plays an exciting role in diagnosis and treatment of cancer, especially breast cancer. The main object of this study was to investigate the effect of the newly synthesized zinc oxide nanoparticles coated by curcumin (Cu-Zno NPs) on the induced mammary gland carcinogenesis in female rats by 7,12-Dimethylbenz(a)anthracene (DMBA). The antitumor efficacy of Cu-Zno NPs was conducted both in vitro and in vivo. In vitro study showed that Cu-Zno NPs inhibited human breast cancer cell line (MCF-7) proliferation with IC50 of 122 4.1 μg/ml. while In vivo study, the administration of Cu-Zno NPs to DMBA-treated rats ameliorated the hyperplastic state of mammary gland carcinogenesis induced by DMBA. Additionally, Cu-Zno NPs administration significantly modulated the activities of ALT and AST, as well as the levels of urea and creatinine in serum. Also Cu-Zno NPs administration improved the antioxidant state by increasing SOD activity and GSH content, accompanied with decreasing MDA content in the mammary tissue.