PATTERNS OF ANTIMOCROBIAL USE AND ITS RESISTANCE PREVALENCE (STUDY AT AIN SHAMS UNIVERSITY SPECIALIZED HOSPITAL "ASUSH")

Abstract

There is no doubt that antimicrobials have played a revolutionary role in healthcare systems worldwide. However, Excessive use of antibiotics leads to the development and spread of multidrug resistant bacteria, currently it is regarded as a global public health crisis threatening our ability to treat common infectious diseases, resulting in prolonged illness, disability and death. In this study we aimed to analyze the use and prescribing patterns of antimicrobials by physicians at Ain-Shams University Specialized Hospital (ASUSH) for inpatients among hospital acquired infections and to determine the prevalence of different types of bacterial resistance among hospital infections. A total of 339 microorganisms were isolated between august 2018 and January 2019 from different sample types .they were identified and studied using VITEK® 2 system. Among (339) bacterial isolates Klebsiella pneumoniae was the most common isolate n=92 (27.1%), followed by E-coli n=60 (17.7%), Staph coag –ve (SCONs) n= 43 (12.7%) and Methecillin resistant staphylococcus aureas (MRSA), Pseudomonas aeruginosa and Acinetobacter baumanni n=33 (9.7%) for each. Antibiotic resistance profiles were not uniform across bacterial species or sample types and even were affected by the departments from which they isolated from where ICUs strains of the MDR bacteria showed higher resistance than the same MDR bacteria isolated from hospital wards. Analysis of our results indicated that E.coli which were highly isolated in summer showed the lowest resistance pattern to most antibiotics specially gentamycin and amikacin unlike A.baumanni & P. aeruginosa which were highly resistant to the same antibiotics.