Assessment of Mothers' Knowledge towards Care of Their Children Suffering from Methylmalonic Acidemia (MMA)

Abstract

ethylmalonic Acidemia (MMA) is an inborn error of metabolism resulting from genetic defects in Methylmalonyl-CoA Mutase (MCM). This enzyme is encoded by the MUT gene and is required for the degradation of odd-chain fatty acids, the amino acids valine, isoleucine, methionine, and threonine, and cholesterol. It an autosomal recessive metabolic disorder that can be classified into two types: (1) vitamin B12-responsive and (2) vitamin B12-non-responsive. MMA is treated with a low-protein, high-calorie diet, certain medications, antibiotics and, in some cases, organ transplantation. Aim of study: The present study was conducted with the aim of study to assess mothers' knowledge towards care of their children suffering from methylmalonic academia. Research Questions: 1. Are the mothers having satisfactory knowledge about care of their children suffering from MMA? 2. Are the mothers having adequate total reported practices about care of their children suffering from MMA? 3. Are there relation between the mothers' total knowledge and total reported practices towards care of their children suffering from MMA and their characteristics?