Assessment of serum adropin level as a risk factor of ischaemic heart disease in type 2 diabetes mellitus cases

Abstract

Adropin is a newly discovered endogenous bioactive substance that is mainly expressed in the heart, brain, liver and coronary endothelial cells. Adropin is involved in regulating lipid metabolism, improving insulin resistance, protecting vascular endothelial cells, and anti-inflammatory effects. Adropin can increase the endothelial nitric oxide synthase expression, which has a certain endothelial cell protection potential. We investigate the correlation of adropin and ischaemic heart disease in diabetic patients. Aim of study is assessment of serum adropin level as a risk factor for ischaemic heart disease in type 2 diabetes mellitus cases. Patients of both gender (male and female) were included Patients aged from 35-65 years old. Patients candidates were divided into three groups. First group is 30 diabetics type 2 with ischaemic heart disease Second group is 30 diabetics type 2 without ischaemic heart disease Third group is 30 control healthy group. All candidates are subjected to full history taking , physical examination including height, weight, BMI and