Evaluationo f the immunomodulatory effect of exopolysaccharides isolated from Lactic acid bacteria against hepatocarcinogenesis in rats
Ola Mohamed Sayed Khedr;
Abstract
The present work aimed to study the immunomodulatory effect of EPSs isolated from Lactic acid bacteria upon chemically-induced hepatocellular tumors in male rats' model.
The bacterial exopolysaccharides were extracted, purified and identified. Extracted EPSs were characterized by using FTIR which showed different stretches of bonds at different peaks.
A total number of 50 male Swiss albino rats were randomly assorted into five groups (10 for each) as follows:
Group 1 "Normal Control": Animals served as control and they received physiological saline daily orally by gastric gavage for eight constitutive weeks.
Group 2 "DEN": Animals received DEN orally by gastric gavage (diluted in 0.9% normal saline), in a dose of 20 mg/kg b.w. daily five days per week for eight constitutive weeks according to the modified method of Darwish and El-Boghdady (2011).
Group 3 "EPSs": Animals received EPSs at dose level of 100 mg /kg b.w. daily five days per week (Zahran et al., 2017) orally by gastric gavage for eight constitutive weeks.
The bacterial exopolysaccharides were extracted, purified and identified. Extracted EPSs were characterized by using FTIR which showed different stretches of bonds at different peaks.
A total number of 50 male Swiss albino rats were randomly assorted into five groups (10 for each) as follows:
Group 1 "Normal Control": Animals served as control and they received physiological saline daily orally by gastric gavage for eight constitutive weeks.
Group 2 "DEN": Animals received DEN orally by gastric gavage (diluted in 0.9% normal saline), in a dose of 20 mg/kg b.w. daily five days per week for eight constitutive weeks according to the modified method of Darwish and El-Boghdady (2011).
Group 3 "EPSs": Animals received EPSs at dose level of 100 mg /kg b.w. daily five days per week (Zahran et al., 2017) orally by gastric gavage for eight constitutive weeks.
Other data
| Title | Evaluationo f the immunomodulatory effect of exopolysaccharides isolated from Lactic acid bacteria against hepatocarcinogenesis in rats | Other Titles | تقييم التأثير المناعي لعديدة السكريات الخارجيه المعزولة من بكتيريا حمض اللبنيك ضد تكوين سرطان الكبد في الجرذان | Authors | Ola Mohamed Sayed Khedr | Issue Date | 2021 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| BB9140.pdf | 1.46 MB | Adobe PDF | View/Open |
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