Potential Therapeutic Outcomes Of The Addition of Vitamin D to Type 2 Diabetes Mellitus Treatment

Abstract

Diabetes mellitus (DM) is a group of metabolic disorders Characterized by chronic hyperglycaemic condition resulting from defects in insulin secretion insulin action or both. Type2 Diabetes Mellitus (T2DM) is the predominant form of diabetes and account at least 90 % of all cases of DM. Insulin resistance is a risk factor for diabetes. Evidence shows that vitamin D (VD) has an important role in modifying the risk of Type 2 Diabetes Mellitus (T2DM), especially among insulin resistant diabetic patients. Recently a novel association between insulin resistance and vitamin D deficiency has been proposed. Mechanism of involvement of vitamin D in overcoming insulin resistance includes promotion of pancreatic β cell function, enhancement of insulin sensitivity and suppression of pancreatic cells inflammation. In the current research we investigate the association between hypovitaminosis D and T2DM .And also we will study the effect of vitamin D supplementation on glycaemic status, oxidative stress status and inflammatory markers in T2DM patients. Therefore, forty T2DM patients were assessed for diabetic, inflammatory and antioxidant parameters. After VD supplementation for six months for the intervention group of patients (n=20), there was significant improvement in VD level, Homeostatic model assessment of insulin resistance (HOMA - IR), Fasting blood glucose (FBG), glycated haemoglobin (HbA1c), serum insulin, interleukin 6 (IL-6), tumor necrosis factor- α (TNF-α), total antioxidant capacity (TAC), malondialdehyde (MDA). In Conclusion : Vitamin D has a promising effect in treatment of Type 2 Diabetes as there is a significant improvement in glycaemic , inflammatory and oxidative stress parameters in Type 2 Diabetes mellitus patients.