Study of Plasma Endothelin-1 and Interleukin-8 in Neonates with Respiratory Distress Syndrome and in Infants and Children with Bronchial Asthma

Nageh Shehata Mohamed Ali;

Abstract


Respiratory distress syndrome remains the most common cause of death and handicapping in preterm neonates<2l


A potential role for ET-1 in. neonatal RDS was suggested by elevated plasma ET-1 levels noted in sick preterm infants compared with healthy term and preterm infants<6• 7




Koteclta and Coworkers,( 185

reported increased concentrations of


serum IL-8 in cases of neonatal RDS.




Bronchial asthma is the most common chronic disease of childhood, characterized by exacerbations and remissions<14

I ET-1 has a m1mber of activities that may contribute to the process involved in the pathogenesis of asthma<246l



Marini et al.,( 18 have been suggested an important role for IL-8 in

asthma pathogenesis.



The ann of this study was to evaluate the plasma levels of ET-1 and IL-8 in neonates with RDS, and in infants and children with bronchial asthma and to determine whether ET-1 and/or IL-8 are specific
markers for lung injury or not.


Other data

Title Study of Plasma Endothelin-1 and Interleukin-8 in Neonates with Respiratory Distress Syndrome and in Infants and Children with Bronchial Asthma
Other Titles دراسة أندوثيلين -1 وأنترلوكين -8 فى البلازما فى حديثى الولادة المصابين بمتلازمة صعوبة التنفس وفى الأطفال المصابين بالربو الشعبى
Authors Nageh Shehata Mohamed Ali
Issue Date 2001

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