Role Of Circulating Vascular cell adhesion protein – 1 as a Biomarker In Non-alcoholic Fatty Liver Disease

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is strongly associated with obesity, dyslipidemia and insulin resistance. NAFLD often presents as simple steatosis (NAFL) but can progress to non-alcoholic steatohepatitis (NASH) and fibrosis. In addition, NAFLD is an independent risk factor for cardiovascular disease, with recent studies unequivocally showing an increased cardiovascular mortality in NAFLD patients VAP-1 is one of the endothelial cell adhesion molecules that mediate binding of lymphocytes to the endothelium under some conditions. It is primarily expressed in high endothelial venules in peripheral lymph nodes. Furthermore, the expression of VAP-1 is induced and up-regulated by chronic inflammation in the vessels of the tonsil, gut, skin, and synovium. VAP-1 is present on sinusoidal and vascular endothelia in the liver under both normal and inflammatory conditions The aim of the study is to assess the level of vascular cell adhesion molecule 1 (VCAM-1) as non-invasive diagnostic tools for diagnosis of NAFLD degree of fibrosis. To elucidate this aim 60 persons were included in this study divided into 2 groups: Group 1: 30 patients with NAFLD as a study group Group 2: 30 healthy subjects as a control group In the NAFLD group, the mean age was 58.46 years with male predominance (80%).As regard to control group, the mean age was 59.25 years with male predominance 63.3%. There was a statistical significant difference in between NAFLD and control group as regard to weight, waist circumference and BMI. There was high statistical significant difference in between NAFLD, NASH and control groups regarding to Cholesterol, Triglycerides, LDL-C, and Fasting blood glucose.