A retrospective analysis of epidemiology and clinical outcomes of patients with adult gliomas treated in Ain Shams clinical oncology department in the period from 2017 till 2020

Abstract

liomas are the most common malignant brain tumors in adults and comprise a wide array of varying biological aggressiveness. Though the data regarding the epidemiology of gliomas is presented in the literature, but they could vary according to other factors and consequently affecting the outcome. We aim the at analysing retrospectively epidemiological and clinical outcomes of adult glioma patients treated in Ain Shams University hospitals (ASU) in Cairo, Egypt in the period from 2017 till 2020. Convenient sampling of 133 patients with adult brain glioma was done. The primary objective was to analyze the epidemiological and demographic data and to assess progression free survival (PFS) and overall survival (OS) of the study population. Secondary objectives included correlation between different clinical and pathological factors and outcome. One hundred thirty-three participants were included, with a median age of 53, with a male to female ratio of 1.5. Incidence was more common in urban than rural areas (71.9 vs 28.1). Glioblastoma represented sixty percent of the cases, followed by grade II (22.7) then grade III (17.3%). The most common presenting symptom was focal deficits, followed by symptoms of increased intracranial tension. Percentage of