Study of The Relation between 8_Hydroxy-2'-deoxyguanosin (8_OHDG) and Suspicious Thyroid nodule in a Patients with Multinodular Goiter

Abstract

Nodular disease of the thyroid gland is prevalent. The lifetime risk for developing a palpable thyroid nodule is estimated to be 5-10%, However, high resolution ultrasound has revealed thyroid nodules in 19-68% of randomly selected individuals.The condition affects more women than men. Optimal prediction of malignancy in nodular thyroid disease is needed to achieve the best medical and surgical intervention. Fine needle aspiration biopsy (FNAB) is widely used and has improved preoperative prediction of malignancy but still has disadvantages. Therefore researchers have focused on identifying novel biologic markers that might be associated with malignancy in thyroid nodules. 8-Hydroxy-2"-deoxyguanosine(8-OHDG), a product of DNA base modification produced by the oxidation of deoxyguanosine, is widely accepted as a marker of oxidative DNA damage and oxidative stress 8-OHDG used as a biomarker for the measurement of endogenous oxidative DNA damage has been found to be significantly higher in various cancers include thyroid cancer. In this study, we aimed to study the relation between 8_Hydroxy-2'-deoxyguanosin (8_OHDG) and suspicious thyroid nodule in a patients with multinodular goiter.