Mean Platelet Volume VS C-Reactive Protein as a Prognostic Marker in Sepsis in ICU

Abstract

defined as a systemic inflammatory response to confirmed or suspected infection. It is a major cause of morbidity and mortality, and the incidence is rising, probably due to the growing elderly population, antibiotic resistance, immunosuppressive medication and, invasive surgery. Pneumonia is the most common infection leading to sepsis, followed by urinary tract infections and abdominal infections. These infections are usually localized and controlled by the immune system, but they can sometimes spread and cause sepsis. Confronted with a sep¬tic patient with high risk of death, it is mandato¬ry to have a prompt attitude in order to establish a rapid diagnosis and an efficient therapy. For these goals, clinicians need good instruments such as clinical and biological tests, biomarkers, scores or algorithms. Mean platelet volume (MPV) is a measurement that describes the average size of platelets in blood and is thought to be an indicator of platelet activation. In general, the value of MPV should increase when more giant platelets enter the circulation. MPV has remained more of a research tool than a clinical decision-making tool. MPV is ordered routinely as part