Intramyometrium Autologous Platelet-Rich Plasma Injection after Primary caesarean Section for Promotion of caesarean Scar Healing: A Double Blind RCT

Abstract

SD is associated with increased risk of uterine rupture, abnormal placental implantation, uterine scar dehiscence in subsequent pregnancies and scar ectopic pregnancy, also CS defects are reported to be associated with abnormal uterine bleeding and post menstrual spotting (Uppal et al., 2011). Uterine wound healing is of great importance to achieve healthy future pregnancy and allow for vaginal birth after caesarean section, hence minimizing the rate of repeated caesarean sections (Miller et al., 1997). Platelet rich plasma (PRP) is an autologous product derived from whole blood through the process of gradient density centrifugation. Autologous PRP has been shown to be safe and effective in promoting the natural processes of wound healing, soft tissue reconstruction, muscle healing, bone reconstruction and augmentation (Smith et al., 2007). Recently, PRP has been used to promote endometrial growth and improve pregnancy outcome during in vitro fertilization (Chang et al., 2015). The current study investigated the efficacy of intramyometrial injection of autologous PRP on uterine wound healing after primary CS.