Headache among Patients with Epilepsy

Abstract

pilepsy is the most common chronic brain disease and affects people of all ages. More than 50 million people worldwide have epilepsy; nearly 80% of them live in low- and middle-income countries. Headache, especially migraine, is one of the most common comorbidities in epilepsy. In 1906, Gowers first advanced the clinical hypothesis of a relationship between epilepsy and migraine, since the two conditions show a well-recognized clinical, pathophysiological and therapeutic overlap. Headache frequently co-morbid with most chronic diseases such as epilepsy. For instance, a review conducted to see the relationship between headache and epilepsy reported the comorbidity of headache and epilepsy as a result of common genetic mutations and clinical features, but the suggested link is not revealed conclusive evidence of a real causal association. Further, studies also suggested that there are genetic relationships as well as common underlying pathophysiological mechanisms including the imbalance between excitatory and inhibitory neurotransmitters in epilepsy and headache, especially for migraine. Aim of this study was to estimate  Temporal relationship of headache (Pre-ictal, Ictal, Post-ictal) with respect to seizure