Lasheen, Deena S.

deenalasheen@pharma.asu.edu.eg

Interests: Medicinal Chemistry and Drug Discovery,
Internal ID: rp12112
  • 720 Scopus Citations
  • 189 PubMed Citations

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Full Name
Lasheen, Deena S.
 
 
Scopus Author ID
 

Publications

Results 1-20 of 27 (Search time: 0.0 seconds).

Issue DateTitleAuthor(s)
12023Design, Molecular Modelling and Synthesis of Novel Benzothiazole Derivatives as BCL-2 inhibitorsIsmail, Hoda S.; Khalil, Amira; Taha, Rabah A.; Lasheen, Deena S. ; Abou El Ella, Dalal 
2Dec-2022Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling studyElmenier, Fatma M; Lasheen, Deena ; Abouzid, Khaled 
3Dec-2022Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cellsAbdelhafiz, Abeer H A; Serya, Rabah A T; Lasheen, Deena S. ; Wang, Nessa; Sobeh, Mansour; Wink, Michael; Abouzid, Khaled 
48-Mar-2022Identification of novel furo[2,3-d]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, in vitro and in vivo biological evaluationMansour, Mai A; Oraby, Mamdouh A; Muhammad, Zeinab A; Lasheen, Deena ; Gaber, Hatem M; Khaled A M Abouzid 
55-Oct-2021Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studiesEldeeb, Assem H; Abo-Ashour, Mahmoud F; Angeli, Andrea; Bonardi, Alessandro; Elrazaz, Eman ; Nocentini, Alessio; Gratteri, Paola; Abdel-Aziz, Hatem A; Supuran, Claudiu T; Lasheen, Deena S. 
626-Aug-2020Elaborating piperazinyl-furopyrimidine based scaffolds as phosphoinositol-3-kinase enzyme alpha (PI3Kα) inhibitors to combat pancreatic cancerMansour, Mai A; Lasheen, Deena S. ; Gaber, Hatem M; Khaled A M Abouzid 
7Aug-2020Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitorsHadi, Soha R Abd El; Soliman, Dalia H; Elrazaz, Eman ; Khaled A M Abouzid ; Lasheen, Deena S. 
81-Dec-2019Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancerElmenier, Fatma M; Lasheen, Deena S. ; Khaled A M Abouzid 
9Dec-2019Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibitionElmeligie, Salwa; Aboul-Magd, Asmaa M; Lasheen, Deena S. ; Ibrahim, Tamer M; Abdelghany, Tamer M; Khojah, Sohair M
10Aug-20193D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluationSobhy, Mahitab K; Mowafy, Samar; Lasheen, Deena S. ; Farag, Nahla A; Khaled A M Abouzid 
112019Apoptosis in cancer: from pathogenesis to discovery of advanced selective Bcl-2 family inhibitorsAbbas, Samaa; Abdou, Nermin; Lasheen, Deena S. ; Abou El Ella, Dalal 
12Dec-2018Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modelingAdel, Mai; Serya, Rabah ; Lasheen, Deena S. ; Khaled A M Abouzid 
13Sep-2018Pyrrolopyrimidine, A Multifaceted Scaffold in Cancer Targeted TherapyAdel, Mai; Serya, Rabah A T; Lasheen, Deena S. ; Abouzid, Khaled 
14Sep-2018Chimeric HDAC inhibitors: Comprehensive review on the HDAC-based strategies developed to combat cancerHesham, Heba M; Lasheen, Deena S. ; Khaled A M Abouzid 
1515-Jul-2018Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinomaShahin, Mai I; Roy, Joyeeta; Hanafi, Maha; Wang, Dongyao; Luesakul, Urarika; Chai, Yifeng; Muangsin, Nongnuj; Lasheen, Deena S. ; Neamati, Nouri; Khaled A M Abouzid ; Abou El Ella, Dalal 
1615-Jul-2018Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitorsMilik, Sandra N; Abdel-Aziz, Amal Kamal; Serya, Rabah ; Minucci, Saverio; Lasheen, Deena S. ; Khaled A M Abouzid 
171-Jun-2018Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agentsFawzy, Iten M; Youssef, Khairia M; Lasheen, Deena S. ; Ismail, Nasser Sm; Abouzid, Khaled 
182018Imidazo[2',1':2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling studyEwida, Menna A; Abou El Ella, Dalal ; Lasheen, Deena S. ; Ewida, Heba A; El-Gazzar, Yomna I; El-Subbagh, Hussein I
192018Design, synthesis, molecular docking study, and biological evaluation of salicylaldimine derivatives as potential histone deacetylases inhibitors (HDACi) and anticancer agentsHesham, Heba; Lasheen, Deena S. ; Abouzid, Khaled 
20Oct-2017Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling studyEwida, Menna A; Abou El Ella, Dalal ; Lasheen, Deena S. ; Ewida, Heba A; El-Gazzar, Yomna I; El-Subbagh, Hussein I